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LITHIUM SPECTROSCOPY
The problem
When we give a dose of lithium, we don't know how much of it gets into the brain.
The solution
We could remove bits of the brain and measure lithium concentration directly, but that wouldn't be very convenient. Instead, we've re-tuned our brain scanner so that it can detect lithium.
Our developments
We detect lithium using our MRI scanner and a radiowave transceiver. The technique is safe and quick. We are one of only a few centres in the world who can measure lithium in this ways and so we are constantly working on improvements and developments. This means that it doesn't always go to plan, so please be patient with us.
The experient
We are asking volunteers to take lithium for about a week before having a brain scan. During the brain scan we tune into the behaviour of lithium in a magnetic field. All you have to do is lie still and listen to some music (if you want too).
We would like subjects to enroll in the MRC:LISP study so that we can gather information about brain structure and lithium concentration.
What it involves
- a screening visit (30 minutes and can be done on scan day 1)
- scan 1 (brain structure only: 30 minutes)
- treatment with lithium for about 1 week
- scan 2 (brain structure and possibly lithium levels: 60 minutes)
- a blood test during screening and the second scan
Will you get paid?
Not as such. Direct payment is a poor incentive to enroll, but we do reimburse you for the time you spend in the study. We will also show you the images of your brain and can greate a copy in the following formats:
a glossy photo print out
a desktop background image
an animated .gif of your brain for PC or mobile phone
Who are we looking for?
Male
Aged 18-45
No psychiatric illnesses
No serious medical illnesses
Can you help?
If you are willing to get involved, you should:
Read the information sheet
Contact us to discuss details in person
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